Auswirkungen von Health Check und EU-Konjunkturprogramm auf die ländlichen Entwicklungsprogramme der deutschen Bundesländer

Als Folge des Health Check der Gemeinsamen Agrarpolitik sowie des europäischen Konjunkturprogramms wurden die Mittel des Europäischen Landwirtschaftsfonds zur Entwicklung des ländlichen Raums (ELER) aufgestockt, um damit geeignete Maßnahmen zur Reaktion auf die 'neuen Herausforderungen' (Klimawandel, erneuerbare Energien, Wassermanagement, Biodiversität, Umstrukturierung des Milchsektors) zu ergreifen. Dieser Bericht analysiert die Änderungen, die die deutschen Bundesländer daraufhin im Jahr 2009 in ihren ländlichen Entwicklungsprogrammen vorgenommen haben. Die Analyse zeigt den großen Unterschied, der zwischen der formalen Anrechnung dieser zusätzlichen Mittel auf Maßnahmen gemäß den Prioritäten des Health Check und der tatsächlichen Mittelverteilung in den Programmen besteht. Umschichtungen von frei werdenden Mitteln in andere Maßnahmen führen in der Summe zu einer Stärkung von Maßnahmen, die vor allem eine Einkommensstützung landwirtschaftlicher Betriebe bewirken und kaum mit anspruchsvollen Bedingungen an zusätzliche Umweltleistungen der Landwirtschaft verknüpft sind. -- As a result of the Health Check of the Common Agricultural Policy and the European Economic Recovery Plan, resources of the European Agricultural Funds for Rural Development (EAFRD) were increased in order to take appropriate measures against the 'new challenges' (climate change, renewable energies, water management, biodiversity, restructuring of the dairy sector). This report analyses how the German federal states (Länder) in 2009 adjusted their Rural Development Programmes to these requirements. The analysis shows the clear difference between the formal assignment of additional funds towards measures according to the Health Check priorities, and the actual distribution of funds in the programmes. Shifting of released funds to other measures leads to a strengthening of measures which primarily sustain incomes of agricultural holdings. These measures are hardly tied to additional environmental benefits as a condition for support.Ländliche Entwicklung,ELER,Gemeinsame Agrarpolitik,Health Check,Rural development,EAFRD,Common Agricultural Policy

Untersuchung über Nutzen und Wirkungen der Flurbereinigung in Niedersachsen: Endbericht für ein Forschungsvorhaben im Auftrag des Niedersächsischen Ministeriums für den ländlichen Raum, Ernährung, Landwirtschaft und Verbraucherschutz

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Evaluation von Maßnahmen der Schwerpunkte 1 und 2 der ELER-Verordnung: Ableitung von Indikatoren auf der Basis vorhandener Daten

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Throat Swabs Are Necessary to Reliably Detect Carriers of Staphylococcus aureus

The anterior nares are the most important screening site of colonization with Staphylococcus aureus. We screened 2966 individuals for S. aureus carriage with swabs of both nares and throat. A total of 37.1% of persons were nasal carriers, and 12.8% were solely throat carriers. Screening of throat swabs significantly increases the sensitivity of detection among carriers by 25.7

Verordnungsentwurf der EU-Kommission zur künftigen Förderung der Entwicklung des ländlichen Raums: Vergleich zur derzeitigen Ausgestaltung der Förderpolitik und Kommentierung der Änderungen

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Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing.

Research into ageing and its underlying molecular basis enables us to develop and implement targeted interventions to ameliorate or cure its consequences. However, the efficacy of interventions often differs widely between individuals, suggesting that populations should be stratified or even individualized. Large-scale cohort studies in humans, similar systematic 56 studies in model organisms, and detailed investigations into the biology of ageing can provide individual validated biomarkers and mechanisms, leading to recommendations for targeted interventions. Human cohort studies are already ongoing, and can be supplemented by in silico simulations. Systematic studies in animal models are made possible by the use of inbred strains, or genetic reference populations of mice. Combining both, the comprehensive picture of the various determinants of ageing and healthspan can be studied in detail, and an appreciation of the relevance of results from model organisms to humans emerges. The interactions between genotype and environment, particularly the psychosocial environment, are poorly studied in both humans and model organisms, presenting serious challenges to any approach to a personalized medicine of ageing. To increase success of preventive interventions, we argue that there is a pressing need for an individualized evaluation of interventions such as physical exercise, nutrition, nutraceuticals and calorie restriction mimetics as well as psychosocial and environmental factors, separately and in combination. The expected extension of healthspan enables us to refocus healthcare spending on individual prevention starting in late adulthood, and on the brief period of morbidity at very old age

Percutaneous dilatational tracheotomy in high-risk ICU patients

BACKGROUND Percutaneous dilatational tracheotomy (PDT) has become an established procedure in intensive care units (ICU). However, the safety of this method has been under debate given the growing number of critically ill patients with high bleeding risk receiving anticoagulation, dual antiplatelet therapy (DAPT) or even a combination of both, i.e. triple therapy. Therefore, the purpose of this study, including such a high proportion of patients on antithrombotic therapy, was to investigate whether PDT in high-risk ICU patients is associated with elevated procedural complications and to analyse the risk factors for bleeding occurring during and after PDT. METHODS PDT interventions conducted in ICUs at 12 European sites between January 2016 and October 2019 were retrospectively analysed for procedural complications. For subgroup analyses, patient stratification into clinically relevant risk groups based on anticoagulation and antiplatelet treatment regimens was performed and the predictors of bleeding occurrence were analysed. RESULTS In total, 671 patients receiving PDT were included and stratified into four clinically relevant antithrombotic treatment groups: (1) intravenous unfractionated heparin (iUFH, prophylactic dosage) (n = 101); (2) iUFH (therapeutic dosage) (n = 131); (3) antiplatelet therapy (aspirin and/or P2Y12 receptor inhibitor) with iUFH (prophylactic or therapeutic dosage) except for triple therapy (n = 290) and (4) triple therapy (DAPT with iUFH in therapeutic dosage) (n = 149). Within the whole cohort, 74 (11%) bleedings were reported to be procedure-related. Bleeding occurrence during and after PDT was independently associated with low platelet count (OR 0.73, 95% CI 0.56, 0.92, p = 0.009), chronic kidney disease (OR 1.75, 95{\%} CI 1.01, 3.03, p = 0.047) and previous stroke (OR 2.13, 95{\%} CI 1.1, 3.97, p = 0.02). CONCLUSION In this international, multicenter study bronchoscopy-guided PDT was a safe and low-complication airway management option, even in a cohort of high risk for bleeding on cardiovascular ICUs. Low platelet count, chronic kidney disease and previous stroke were identified as independent risk factors of bleeding during and after PDT but not triple therapy

Phosphodiesterase 3B Is Localized in Caveolae and Smooth ER in Mouse Hepatocytes and Is Important in the Regulation of Glucose and Lipid Metabolism

Cyclic nucleotide phosphodiesterases (PDEs) are important regulators of signal transduction processes mediated by cAMP and cGMP. One PDE family member, PDE3B, plays an important role in the regulation of a variety of metabolic processes such as lipolysis and insulin secretion. In this study, the cellular localization and the role of PDE3B in the regulation of triglyceride, cholesterol and glucose metabolism in hepatocytes were investigated. PDE3B was identified in caveolae, specific regions in the plasma membrane, and smooth endoplasmic reticulum. In caveolin-1 knock out mice, which lack caveolae, the amount of PDE3B protein and activity were reduced indicating a role of caveolin-1/caveolae in the stabilization of enzyme protein. Hepatocytes from PDE3B knock out mice displayed increased glucose, triglyceride and cholesterol levels, which was associated with increased expression of gluconeogenic and lipogenic genes/enzymes including, phosphoenolpyruvate carboxykinase, peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein 1c and hydroxyl-3-methylglutaryl coenzyme A reductase. In conclusion, hepatocyte PDE3B is localized in caveolae and smooth endoplasmic reticulum and plays important roles in the regulation of glucose, triglyceride and cholesterol metabolism. Dysregulation of PDE3B could have a role in the development of fatty liver, a condition highly relevant in the context of type 2 diabetes